解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND & AIMS:A 3-dimensional (3D) culture system for immortalized human hepatocytes (HuS-E/2 cells) recently was shown to support the lifecycle of blood-borne hepatitis C virus (HCV). We used this system to identify proteins that are active during the HCV lifecycle under 3D culture conditions. METHODS:We compared...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.05.014
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND & AIMS:According to the National Center for Health Statistics (NCHS), chronic liver disease and cirrhosis is the 12(th) leading cause of death in the United States. However, this single descriptor might not adequately enumerate all deaths from liver disease. The aim of our study was to update data on liver m...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.04.005
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND & AIMS:Human primary liver cancer is classified into biologically distinct subgroups based on cellular origin. Liver cancer stem cells (CSCs) have been recently described. We investigated the ability of distinct lineages of hepatic cells to become liver CSCs and the phenotypic and genetic heterogeneity of pr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.03.013
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND & AIMS:The cyclic adenosine monophosphate (cAMP) and Ca(2+) signaling pathways synergize to regulate many physiological functions. However, little is known about the mechanisms by which these pathways interact. We investigated the synergy between these signaling pathways in mouse pancreatic and salivary glan...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.03.047
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND & AIMS:Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is a challenge to determine a patient's prognosis. We aimed to identify new prognostic markers of patients with HCC treated by liver resection. METHODS:We collected 314 HCC samples from patients at Bordeaux (1998-200...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.03.051
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND & AIMS:Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.02.005
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease. Interferon-α (IFNα) is an important component of anti-HCV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been investigated for their antiviral effects. However, all of the genes require...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.02.026
更新日期:2013-06-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pa...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2012.11.037
更新日期:2013-06-01 00:00:00
abstract::Approximately 10% of persons 70 years old or older are now diagnosed with pancreatic cysts, but it is not clear which ones require additional analysis, interventions, or follow-up. Primary care doctors rely on gastroenterologists for direction because no one wants to miss a diagnosis of pancreatic cancer, but meanwhil...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2013.01.073
更新日期:2013-06-01 00:00:00
abstract::Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are benign hepatocellular tumors that develop most frequently in women without cirrhosis. Genomic approaches have identified signaling pathways related to these benign hepatocyte proliferations. FNH, a polyclonal lesion, is characterized by local vascula...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2013.02.032
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND & AIMS:Individuals with human immunodeficiency virus (HIV) infection frequently also are infected with hepatitis C virus (HCV) (co-infection), but little is known about its effects on the progression of HIV-associated disease. We aimed to determine the effects of co-infection on mortality from HIV and/or acq...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2012.12.026
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND & AIMS:In intestinal inflammation the gut microbiota induces an innate immune response by activating epithelial and immune cells that initiate or maintain inflammation. We investigated whether the microbiota also can activate local microvascular cells and induce angiogenesis. METHODS:Human intestinal microv...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.11.005
更新日期:2013-03-01 00:00:00
abstract::Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.09.016
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND & AIMS:The transcription factor nuclear factor-κB (NF-κB) (a heterodimer of NF-κB1p50 and RelA) is activated rapidly in acute pancreatitis (AP). However, it is not clear whether NF-κB promotes or protects against AP. We used the NF-κB inhibitor protein, inhibitor of κB (IκB)α, to study the roles of NF-κB in ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.09.058
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND & AIMS:Noninvasive methods are needed to identify clinically significant portal hypertension (CSPH) and esophageal varices (EVs) in patients with compensated cirrhosis. We looked for markers of the presence of CSPH and EVs in patients with cirrhosis. METHODS:We performed a cross-sectional study that include...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.10.001
更新日期:2013-01-01 00:00:00
abstract::Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role in the pathogenesis of inflammatory bowel disease (IBD). The brain-gut axis involves interactions among the neural components, including (1) the autonomic nervous system, (2) the central nervous system, (3) the stress system (hyp...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2012.10.003
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND & AIMS:After liver injury, bone marrow-derived liver sinusoidal endothelial cell progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial cells (LSECs). After partial hepatectomy, BM SPCs provide hepatocyte growth factor, promote hepatocyte proliferation, and are necessary for norma...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.08.008
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND & AIMS:We aimed to characterize offers of organs to candidates awaiting liver transplantation (LT). METHODS:We analyzed data from the United Network for Organ Sharing registry on all US LT candidates with nonfulminant disease who were offered livers from February 1, 2005, to January 31, 2010, and ultimately...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.07.105
更新日期:2012-11-01 00:00:00
abstract::In the TMC435-C101 study, 6 patients infected with hepatitis C virus genotype 1 were treated with the protease inhibitor TMC435 (200 mg once daily) as monotherapy for 5 days. Approximately 1.5 years later, 5 of these patients were re-treated with TMC435 (200 mg once daily) plus pegylated interferon alfa-2a and ribavir...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1053/j.gastro.2012.07.117
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND & AIMS:T helper (Th) 17 cells that express the retinoid-related orphan receptor (ROR) γt contribute to the development of colitis in mice, yet are found in normal and inflamed intestine. We investigated their development and functions in intestines of mice. METHODS:We analyzed intestinal Th17 cells in healt...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.07.108
更新日期:2012-11-01 00:00:00
abstract::We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...
journal_title:Gastroenterology
pub_type: 社论
doi:10.1053/j.gastro.2012.08.009
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND & AIMS:CD8(+) T cells that produce interleukin (IL)-17 (Tc17 cells) promote inflammation and have been identified in tumors. We investigated their role in the pathogenesis of gastric cancer. METHODS:We used flow cytometry analyses to determine levels and phenotype of Tc17 cells in blood and tumor samples fr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.06.010
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND & AIMS:People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk of cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hod...
journal_title:Gastroenterology
pub_type: 杂志文章,收录出版
doi:10.1053/j.gastro.2012.07.013
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND & AIMS:The aim of this study was to generate an improved prognostic model for predicting recurrence in liver transplant candidates with hepatocellular carcinoma (HCC). METHODS:Predictors of recurrence were tested by a Cox model analysis in a training cohort of 537 patients transplanted for HCC. A prognostic...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.05.052
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND & AIMS:Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are potent antiviral agents that might have additive or synergistic antiviral activity in treatment of patients with chronic hepatitis B (CHB). We compared the efficacy and safety of ETV monotherapy with those of a combination of ETV and TDF. ME...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1053/j.gastro.2012.05.037
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND & AIMS:The risk for colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) could have changed over time, with changes in treatment options. We studied CRC risk in a nationwide cohort of 47,374 Danish patients with IBD over a 30-year period. METHODS:We determined relative risk (RR) values ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.04.016
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND & AIMS:Early embryogenesis involves cell fate decisions that define the body axes and establish pools of progenitor cells. Development does not stop once lineages are specified; cells continue to undergo specific maturation events, and changes in gene expression patterns lead to their unique physiological fu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.04.011
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatitis C virus (HCV) uses several host factors to infect and replicate in human hepatocytes. Cyclophilin A (CypA) is required for viral replication, and CypA inhibitors are in development. We investigated the effects of nonsynonymous single nucleotide polymorphisms (SNPs) in the region of peptidyl-...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.04.053
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND & AIMS:MicroRNAs (miRNAs) have been implicated in the development and progression of human cancers. We investigated the roles and mechanisms of miR-26a in human cholangiocarcinoma. METHODS:We used in situ hybridization and quantitative reverse transcriptase polymerase chain reaction to measure expression of...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.03.045
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND & AIMS:Prostaglandin-endoperoxide synthase (Ptgs)2 is an enzyme involved in prostaglandin production during the response to mucosal damage. Its expression is regulated, in part, by messenger RNA (mRNA)-binding proteins that control the stability of Ptgs2 mRNA. We used a precise system of colonic injury and r...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.03.037
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND & AIMS:Circulating membrane-shed microparticles (MPs) participate in regulation of vascular tone. We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension. METHODS:We ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.03.040
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND & AIMS:Fish is a rich source of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Although consumption of fish and n-3 PUFA has been reported to protect against the development of some types of cancer, little is known ab...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.02.018
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND & AIMS:Patients with chronic hepatitis B virus (HBV) infection have a high risk for developing hepatocellular carcinoma (HCC). Patients with lower levels of hepatitis B surface antigen (HBsAg) have higher chances of losing HBsAg than those with high levels. However, little is known about whether higher level...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.02.007
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND & AIMS:Previous studies have suggested that dietary folic acid (FA) can protect against certain types of cancers. However, the findings have varied, and the mechanisms by which FA exerts chemopreventive effects remain to be clarified. We examined the effects of FA supplementation on DNA methylation, gene exp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.12.058
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND & AIMS:Tumors that develop in patients with Crohn's disease tend be multifocal, so field cancerization (the replacement of normal cells with nondysplastic but tumorigenic clones) might contribute to intestinal carcinogenesis. We investigated patterns of tumor development from pretumor intestinal cell clones....
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.12.004
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.12.047
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND & AIMS:Mutational inactivation of adenomatous polyposis coli (APC) is an early event in colorectal cancer (CRC) progression that affects the stability and increases the activity of β-catenin, a mediator of Wnt signaling. Progression of CRC also involves inactivation of signaling via transforming growth facto...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.11.026
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND & AIMS:Acute-on-chronic liver failure (ACLF) develops in patients with chronic liver disease and has high mortality. Mobilization of bone marrow-derived stem cells with granulocyte colony-stimulating factor (G-CSF) could promote hepatic regeneration. METHODS:Consecutive patients with ACLF were randomly assi...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2011.11.027
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND & AIMS:Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process. Fibromodulin is a liver proteoglycan that regulates extracellular matrix organization and is induced by fibrogenic stimuli. We propose that fibromodulin contributes to the pathogenes...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.11.029
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND & AIMS:The complications of diverticulosis cause considerable morbidity in the United States; health care expenditures for this disorder are estimated to be $2.5 billion per year. Many physicians and patients believe that a high-fiber diet and frequent bowel movements prevent the development of diverticulosi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.10.035
更新日期:2012-02-01 00:00:00